Handbook On The Toxicology Of Metals

Handbook on the Toxicology of Metals PDF
Author: Monica Nordberg
Publisher: Elsevier
ISBN: 9780080546100
Size: 47.41 MB
Format: PDF, Kindle
Category : Science
Languages : un
Pages : 1024
View: 5830

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Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more

Handbook On The Toxicology Of Metals Specific Metals

Handbook on the Toxicology of Metals  Specific metals PDF
Author: Lars Friberg
Publisher: Elsevier Science Limited
ISBN: 9780444904423
Size: 41.10 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 704
View: 1428

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Chapters on specific metals include physical and chemical properties, methods and problems of analysis, production and uses, environmental levels and exposures, metabolism, levels in tissues and biological fluids, effects and dose-response relationships, carcinogenicity, mutagenicity, teratogenicity and preventative measures, diagnosis, treatment and prognosis.

Toxicology Of Metals

Toxicology of Metals PDF
Author: Robert A. Goyer
Publisher: Springer Science & Business Media
ISBN: 364279162X
Size: 62.86 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : un
Pages : 467
View: 4407

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An insight into new advances of current interest in metal toxicology, such as mechanisms important in risk-assessment for human health. The book also has chapters on emerging conceptual problems including resistance to metal toxicity effects on gene expression, alongside principles regarding drug-chelation of metals, the potential use of prophyrins as indicators of metal exposure and toxicity. The toxicology of specific metals of major public health concern are discussed in depth, such as mercury, aluminum, arsenic, chromium, and cadmium. Of interest to basic scientists as well as public health administrators.

Toxicology Of Metals

Toxicology of Metals PDF
Author: Louis W. Chang
Publisher: CRC Press
ISBN: 9780873718035
Size: 21.75 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 1232
View: 5763

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This volume offers the most comprehensive presentation available on metal toxicology. It discusses not only metals but also the toxic endpoints, such as neurotoxicity, renal toxicity, and cancer induction. Chapters are written by experts in their respective fields, focusing on carcinogenesis and human exposures and highlighting the major aspects and issues of toxicity in general.

Metal Toxicology Handbook

Metal Toxicology Handbook PDF
Author: Debasis Bagchi
Publisher: CRC Press
ISBN: 0429795742
Size: 22.94 MB
Format: PDF, Mobi
Category : Health & Fitness
Languages : en
Pages : 490
View: 460

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Heavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson’s and Alzheimer’s diseases, cardiovascular disorders, and several others. Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting. Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals. Key Features Discusses the pathology of metal toxicity Highlights the benefits of metals Explains the mechanism and salient features of restoring metabolic homeostasis Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals. The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.

Risk Assessment For Human Metal Exposures

Risk Assessment for Human Metal Exposures PDF
Author: Gunnar F. Nordberg
Publisher: Academic Press
ISBN: 9780128042274
Size: 76.22 MB
Format: PDF
Category : Medical
Languages : en
Pages : 348
View: 883

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Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment. Covers fundamental risk assessment concerns for the effects of metals on human health Provides an easy-to-use structure to quickly locate specific methods Uses case studies to illustrate the methods and theories described Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health

Measuring Lead Exposure In Infants Children And Other Sensitive Populations

Measuring Lead Exposure in Infants  Children  and Other Sensitive Populations PDF
Author: National Research Council
Publisher: National Academies Press
ISBN: 030904927X
Size: 65.98 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 356
View: 2679

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Lead is a ubiquitous toxic agent that is especially damaging to the young child and the developing fetus. Unlike many environmental health risks, the risks associated with lead are no longer theoretical but have been observed for many years. Indeed, the first regulation of lead in paint was enacted in the 1920s. Currently, because of growing evidence of lead toxicity at lower concentrations, the U.S. Centers for Disease Control and Prevention recently lowered its lead-exposure guideline to 10 ug/dl lead in blood from 25 ug/dl. Measuring Lead Exposure in Infants, Children, and Other Sensitive Populations addresses the public health concern about the logistics and feasibility of lead screening in infants and children at such low concentrations. This book will serve as the basis for all U.S. Public Health Service activities and for all state and local programs in monitoring lead.

Fish Physiology Homeostasis And Toxicology Of Essential Metals

Fish Physiology  Homeostasis and Toxicology of Essential Metals PDF
Author:
Publisher: Academic Press
ISBN: 0123786371
Size: 55.37 MB
Format: PDF, Docs
Category : Technology & Engineering
Languages : en
Pages : 520
View: 1948

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Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. The companion volume, Homeostasis and Toxicology of Non-Essential Metals, Volume 31B, covers metals that have no known nutritive function in fish at present, but which are toxic at fairly low levels, such as Ag, Al, Cd, Pb, Hg, As, Sr, and U. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers. All major essential metals of interest are covered in metal-specific chapters Each metal-specific chapter is written by fish physiologists/toxicologists who are recognized authorities for that metal A common format is featured throughout this two volume edition

Poisoning Diagnosis And Treatment

Poisoning Diagnosis and Treatment PDF
Author: J.A. Vale
Publisher: Springer Science & Business Media
ISBN: 940116763X
Size: 46.26 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 232
View: 1389

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In the last decade, the incidence of acute poisoning in the developed world has risen considerably, so that hospital admissions from this cause now repre~ sent a significant part of the work load of most medical units. The purpose of this book is to provide an up-to-date account of the diag nosis and treatment of all the clinically important poisons. Throughout the text the aim has been to emphasize the mechanisms of toxicity - wherever they are known - so that a rational approach to therapy may be devised. In addition, substantial chapters have been devoted to the psychiatric assess ment of self-poisoned patients and to the role of the laboratory. Two styles of presentation have been adopted. Certain topics are discussed in depth either because of their clinical importance or because recent data have become available concerning pathophysiology or treatment. In contrast, when subjects have been well described previously in general medical texts, for example, carbon monoxide poisoning, the discussion is far more brief and to the point. A similar style has been adopted with recently introduced drugs, where little is known about the effects in overdose. The value of cer tain chapters, especially those on poisonous plants and snake bites, has been enhanced by the inclusion of a large number of colour photographs.