Molecular And Translational Vascular Medicine

Molecular and Translational Vascular Medicine PDF
Author: Jonathon W. Homeister
Publisher: Springer Science & Business Media
ISBN: 1617799068
Size: 67.74 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : un
Pages : 338
View: 3776

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Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.

Cellular And Molecular Pathobiology Of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease PDF
Author: Monte Willis
Publisher: Academic Press
ISBN: 0124055257
Size: 79.85 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : un
Pages : 338
View: 5761

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Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Textbook Of Vascular Medicine

Textbook of Vascular Medicine PDF
Author: Rhian M. Touyz
Publisher: Springer
ISBN: 3030164810
Size: 19.23 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 503
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This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Vascular Tumors And Developmental Malformations

Vascular Tumors and Developmental Malformations PDF
Author: Paula E. North
Publisher: Humana Press
ISBN: 9781617797422
Size: 73.22 MB
Format: PDF
Category : Medical
Languages : un
Pages : 280
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Vascular Tumors and Developmental Malformations comprehensively covers the pathogenesis, diagnostic histologic and molecular evaluation, and clinical management of vascular anomalies presenting in infancy and childhood. This volume offers a new resource for clinical pathologists, molecular diagnosticians, and basic scientists in the field of vascular medicine and biology. It provides fundamental information on vascular malformations and hemangiomas, while including current and cutting-edge information on the pathogenic mechanisms of the disease and implications for molecular diagnostics. In particular, chapters highlight recent advancements in the molecular diagnosis of vascular anomalies, the cellular mechanisms that underlie the disorder , new insights into the molecular mechanisms and signaling pathways involved in disease that offer novel targets for diagnosis and therapy, and recent advances in the field regarding the role of the placenta. This volume will provide the medical community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinic pathological entities within the spectrum of vascular anomalies.

Vascular Tumors And Developmental Malformations

Vascular Tumors and Developmental Malformations PDF
Author: Paula E. North
Publisher: Springer
ISBN: 1493932403
Size: 14.39 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 149
View: 4536

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This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention. Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinicopathological entities within the spectrum of vascular anomalies.

Cellular And Molecular Pathobiology Of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease PDF
Author: Monte S. Willis
Publisher:
ISBN: 9780124052062
Size: 18.38 MB
Format: PDF, ePub
Category : Medical
Languages : un
Pages : 320
View: 884

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Focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine.

Endocrinology Of The Heart In Health And Disease

Endocrinology of the Heart in Health and Disease PDF
Author: Jonathan C. Schisler
Publisher: Academic Press
ISBN: 0128031123
Size: 71.63 MB
Format: PDF, ePub
Category : Medical
Languages : un
Pages : 378
View: 1451

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Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology

Principles Of Translational Science In Medicine

Principles of Translational Science in Medicine PDF
Author: Martin Wehling
Publisher: Academic Press
ISBN: 9780128204931
Size: 71.59 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 380
View: 2759

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Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

Vascular Medicine A Companion To Braunwald S Heart Disease E Book

Vascular Medicine  A Companion to Braunwald s Heart Disease E Book PDF
Author: Mark Creager
Publisher: Elsevier Health Sciences
ISBN: 0323636012
Size: 17.36 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 880
View: 3818

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With authoritative coverage of everything from recent discoveries in the field of vascular biology to recent clinical trials and evidence-based treatment strategies, Vascular Medicine, 3rd Edition, is your go-to resource for improving your patients’ cardiovascular health. Part of the Braunwald family of renowned cardiology references, this updated volume integrates a contemporary understanding of vascular biology with a thorough review of clinical vascular diseases, making it an ideal reference for vascular medicine specialists, general cardiologists, interventional cardiologists, vascular surgeons, and interventional radiologists. Incorporates technologic advances in vascular imaging – including ultrasound, MRI, CTA, and catheter-based angiography – along with more than 230 new figures, providing an up-to-date and complete view of the vascular system and vascular diseases. Covers novel antithrombotic therapies for peripheral artery disease and venous thromboemboism, advances in endovascular interventions for aortic aneurysms, and today’s best surgical treatments for vascular diseases. Includes seven new chapters: Pathobiology of Aortic Aneurysms; Pathobiology and Assessment of Cardiovascular Fibrosis; Large Vessel Vasculitis; Medium and Small Vessel Vasculitis; Epidemiology and Prognosis of Venous Thromboembolic Disease; Fibromuscular Dysplasia; and Dermatologic Manifestations of Vascular Disease. Discusses methods for aggressive patient management and disease prevention to ensure minimal risk of further cardiovascular problems. Keeps you current with ACC/AHA and ECC guidelines and the best ways to implement them in clinical practice.

Introduction To Translational Cardiovascular Research

Introduction to Translational Cardiovascular Research PDF
Author: Dennis V. Cokkinos
Publisher: Springer
ISBN: 3319087983
Size: 64.40 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 610
View: 7649

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The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.